This classic text continues to provide the basis for understanding genetic principles behind quantitative differences, and extends these concepts to the segregation of genes that cause genetic variation in quantitative traits. *A new chapter on Quantitative Trait Loci (QTLs) *Fully revised chapter on natural selection with more emphasis on maintenance of variation by mutation-selection balance *More evolutionary and molecular examples and problems *Essential maths necessary for using computer algorithms *Addresses potential applications in animal and plant breeding, and human disease Contents: Part 1 Genetic constitution of a population: frequencies of genes and genotypes; Hardy-Weinberg equilibrium; non-random mating; problems. Part 2 Changes of gene frequency: migration; mutation; selection; equilibria; polymorphism; problems. Part 3 Small populations I - changes of gene frequency under simplified conditions: the idealized population; sampling; inbreeding; problems. Part 4 Small populations II - less simplified conditions: effective population size; mutation, migration and selection; random drift in natural populations; polymorphism; problems. Part 5 Small populations III - pedigreed populations and close inbreeding: pedigreed populations; regular systems of inbreeding; problems. Part 6 Continuous variation: metric characters; properties of metric characters; problems. Part 7 Values and means: population mean; average effect; breeding value; dominance deviation; interaction deviation; problems. Part 8 Variance: components of variance; genetic components of variance; correlation and interaction between genotype and environment; environmental variance; summary of variance partitioning; problems. Part 9 Resemblance between relatives: genetic covariance; environmental covariance; phenotypic resemblance; problems. Part 10 Heritability: estimation of heritability; twins and human data; assorative mating; precision of estimates and design of experiments; problems. Part 11 Selection I - the response and its prediction: responses to selection; measurement of response; change of gene frequency under artificial selection; effects of selection on variance; problems. Part 12 Selection II - the results of experiments: short-term results; long-term results; problems. Part 13 Selection III - information from relatives: criteria for selection; index selection; problems. Part 14 Inbreeding and crossbreeding I - changes of mean value: inbreeding depression; heterosis; problems. Part 15 Inbreeding and crossbreeding II - changes of variance: inbreeding; mutation; crossing; problems. Part 16 Inbreeding and crossbreeding III - applications: problems. Part 17 Scale: problems. Part 18 Threshold characters: problems. Part 19 Correlated characters: genetic and environmental correlations; correlated response to selection; genotype-environment interaction; index selection; problems. Part 20 Metric characters under natural selection: natural selection; relationships between metric characters and fitness; responses to natural selection; equilibrium populations; origin of variation by mutation; maintenance of genetic variation; problems. Part 21 Quantitative trait loci: major genes; methods for mapping QTLs; genetic and statistical considerations; experimental results; from QTL to gene; problems.
